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Amaryl tablet 2mg (glimepiride)

351.00$877.50$

Amaryl tablets (glimepiride)
Drug Description
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Type 2 Diabetes: Learn the Warning Signs
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AMARYL
(glimepiride) Tablets

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Amaryl tablet 2mg (glimepiride) is an oral sulfonylurea that contains the active ingredient glimepiride. Chemically, glimepiride is identified as 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea (C24H34N4O5S) with a molecular weight of 490.62. Glimepiride is a white to yellowish-white, crystalline, odorless to practically odorless powder and is practically insoluble in water. The structural formula is:

AMARYL (glimepiride) Structural Formula Illustration
AMARYL tablets contain the active ingredient glimepiride and the following inactive ingredients: lactose (hydrous), sodium starch glycolate, povidone, microcrystalline cellulose, and magnesium stearate. In addition, AMARYL 1 mg tablets contain Ferric Oxide Red, AMARYL 2 mg tablets contain Ferric Oxide Yellow and FD&C Blue #2 Aluminum Lake, and AMARYL 4 mg tablets contain FD&C Blue #2 Aluminum Lake.

For Consumers
What are the possible side effects of glimepiride?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

severe skin rash, itching, redness, or irritation;
pale skin, easy bruising or bleeding, fever, unusual weakness;
numbness or tingly feeling;
trouble breathing;
feeling like you might pass out;
dark urine, clay-colored stools;
upper stomach pain, low fever, jaundice (yellowing of the skin or…
Read All Potential Side Effects and See Pictures of Amaryl Tablets »
Indications & Dosage
Type 2 Diabetes Warning Signs
Type 2 Diabetes: Learn the Warning Signs
Diabetes Friendly Dining
Type 2 Diabetes Quiz
INDICATIONS

glimepiride is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Important Limitations Of Use

AMARYL should not be used for the treatment of type 1 diabetes mellitus or diabetic ketoacidosis, as it would not be effective in these settings.

DOSAGE AND ADMINISTRATION

Recommended Dosing

AMARYL should be administered with breakfast or the first main meal of the day.

The recommended starting dose of AMARYL is 1 mg or 2 mg once daily. Patients at increased risk for hypoglycemia (e.g., the elderly or patients with renal impairment) should be started on 1 mg once daily [see WARNINGS AND PRECAUTIONS and Use in Specific Populations].

After reaching a daily dose of 2 mg, further dose increases can be made in increments of 1 mg or 2 mg based upon the patient’s glycemic response. Uptitration should not occur more frequently than every 1-2 weeks. A conservative titration scheme is recommended for patients at increased risk for hypoglycemia [see WARNINGS AND PRECAUTIONS and Use in Specific Populations].

The maximum recommended dose is 8 mg once daily.

Patients being transferred to AMARYL from longer half-life sulfonylureas (e.g., chlorpropamide) may have overlapping drug effect for 1-2 weeks and should be appropriately monitored for hypoglycemia.

When colesevelam is coadministered with glimepiride, maximum plasma concentration and total exposure to glimepiride is reduced. Therefore, AMARYL should be administered at least 4 hours prior to colesevelam.

HOW SUPPLIED

Dosage Forms And Strengths

AMARYL is formulated as tablets of:

1 mg (pink, flat-faced, oblong with notched sides at double bisect, imprinted with “AMA RYL” on one side)
2 mg (green, flat-faced, oblong with notched sides at double bisect, imprinted with “AMA RYL” on one side)
4 mg (blue, flat-faced, oblong with notched sides at double bisect, imprinted with “AMA RYL” on one side)